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In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks

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Additionally, its ability to reduce stress by stabilizing the hypothalamic-pituitary-adrenal (HPA) axis and lowering cortisol levels may further alleviate depressive symptoms (3)

The practical solution: when you get to what you estimate is the last dose in a vial, reconstitute your next vial first and draw the new dose from the fresh vial