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Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

It can also cause muscle twitching, so-called tics, which are particularly noticeable in the eyes

HIT explains that it is a clinical situation which involves accumulation of histamine in the body

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