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The categories of alkylating agents include nitrogen mustards, nitrosoureas, alkylsulfonates and platinum coordination complexes
Immune activation Pro-angiogenic factors in tumors induce down-regulation of adhesion molecules on endothelial cells in the tumor vasculature and induce anergy to inflammatory signals such as TNF and IL-1
10.1016/s1876-3553(09)60023-5 119 YounisN.MohamedM
NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
