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Description
This transgenic mouse overexpresses the human amyloid precursor protein (APP) carrying two familial AD mutations: The Swedish mutation (KM670/671NL), which increases total A production by enhancing -secretase cleavage, and the Indiana mutation (V717F), which alters -secretase cleavage to favor production of the more aggregation-prone amyloid-beta 142 peptide (A 142 ) [464467]

The tumour size increased rapidly in the saline group

In premenopausal women, estrogen promotes fat oxidation, meaning your body preferentially burns fat for energy

It is involved in the formation of monoamine neurotransmitters such as serotonin and norepinephrine (28)
