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It promotes neurogenesis and enhances the action of neurotrophic factors. An ongoing clinical trial (NCT03641404) testing ergothioneine supplementation (25 mg three times weekly) in elderly individuals with mild cognitive impairment shows promising preliminary results: Significant increases in blood ergothioneine levels Improvements in global cognitive performance scores Trending improvements across multiple cognitive assessments Reduction in neurofilament light protein (a marker of neuronal injury) Recent 2025 research revealed that ergothioneine significantly increases brain-derived neurotrophic factor (BDNF) expression in nerve cells [8]

Sirtuin 5 (SIRT5), which is overexpressed in lung cancer, decrease the succinylation of GLS to regulate ammonia production and ammonia-induced autophagy [67]

Cell Host Microbe 29, 17571773.e10

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid beta production and BACE1 in a mouse model of Alzheimers disease: implications for neuroprotection and lifespan extension