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Despite its high prevalence, the contributing factors and mechanisms underlying brainkidney dysfunction in CKD remain poorly understood

particularly inclusion of "among others"... Response: We have replaced this sentence with: While these three components are all directly related to ghrelin, one cannot deny the complex interrelationships between ghrelin and the multitude of other systems beyond simply the typical feeding circuitry of this peptide. Line 365-6: Statement "In addition to this, similar situations that lead to drug relapse also lead to relapse in dieting individuals (Nair et al., 2011)" is confusing

Strengthens Hair Roots: Weak roots are a primary cause of excessive hair shedding