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doi: 10.1158/0008-5472.CAN-12-3386

The experimental findings demonstrated that grape seed PCs inhibited the activation and nuclear translocation of NF-kB while downregulating the expression of proinflammatory cytokines such as TNF- , IL-1, and IL-6, as well as cyclooxygenase-2

Hyperglycemia-induced interactions between AGEs and their receptor, receptor for advanced glycation end products (RAGE), activate NF-B signaling in renal macrophages, thereby amplifying pro-inflammatory cytokines and chemokines that recruit monocytes to the kidney

