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Furthermore, a study found that patients with CDI have already shown lower microbial diversity before antibiotic treatment, further suggesting that changes in gut microbiota diversity are related to the occurrence and development of CDI (Chen et al., 2022)

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Aberrant epigenetic alterations are thought to have a role in cancer progression, and there is data to suggest that a loss of 5 hmC occurs during the early development and progression of melanoma [114]

Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation