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Two uncontrolled studies conducted in participants with cirrhosis found that L-carnitine supplementation was safe to use at doses of 0.9 to 1.2 g/day for eight weeks (125) and 1 g/day for 24 weeks (126) and might be considered to control the frequency of cramps

Role of carnitine Although data in this setting are sparse, consisting of anecdotal case reports, it has been suggested that carnitine supplementation could hasten resolution of coma, prevent development of hepatic dysfunction and reverse mitochondrial metabolic abnormalities in patients with acute VPA intoxication [22,70]

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