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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

The two compounds work through entirely separate biological pathways

Treatment should start with stretching of the plantar fascia, ice massage, and nonsteroidal anti-inflammatory drugs

Dihexa mechanism of action suggests potential for enhancing the mind-muscle connection
