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Results: EEDs disrupt male reproduction through multiple pathways: androgen and estrogen receptor interference, oxidative stress induction, mitochondrial dysfunction, and epigenetic modifications

In women with confirmed deficiency, milk levels are typically less than 100 pmol/L (135 ng/L).[9,12,39] A lower milk level threshold of 310 pmol/L (420 ng/L) for adequate infant B 12 intake has been suggested.[28] Three mothers in India with vitamin B 12 deficiency due to very low dietary intake were given a single 50 mcg intramuscular injection of vitamin B 12

notably, BBB permeability determines which gut-derived factors can access the CNS parenchyma [24]

Management: Use cautiously and under medical guidance if prolonged therapy is needed