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More importantly, disruptions in the intestinal barrier and imbalances in gut microbiota could further result in an increase of bacterial lipopolysaccharide and peptidoglycan at the systemic level to amplify systemic inflammation among patients with PACS persistently (Teixeira et al., 2021

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Although direct evidence linking these effects to gut microbiota metrics remains limited, the overlapping mechanistic networks strongly suggest that TCM bioactive compounds may achieve their multi-target therapeutic effects through remodeling gut microbial ecosystems