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During infection, the coronavirus depletes NK cells and impairs their antiviral effects while activating macrophages and other immune cells leading to the cytokine storm ( TREM1 signaling and Acute phase response signaling pathways favors the production of IFN and activation of Th1 and Th17 cells, which are fundamental components of the antiviral response ( Th1 pathway was also observed, which further reinforces the idea that B12 stimulates the antiviral response

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