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Therefore, the recently described cuproptosis involves an evolutionary ancient mechanism, protein lipoylation: notably, few mammalian proteins are lipoylated, and these are concentrated in the tricarboxylic acid cycle, where lipoylation is required for enzymatic function [83]

Those familiar with general peptide dosing principles will recognize this pattern from other receptor-mediated compounds

What are the dangers of long-term intramuscular (IM) vitamin B12 supplementation?
