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Rationale for Combination with Mesotherapy Given that mesotherapy addresses dermal matrix strength, antioxidant support and long-term pigment stabilisation, while picosecond lasers provide active pigment disruption, combining the two can yield synergistic benefits: Laser clears pigment and stimulates regeneration

Well designed, properly powered, RCT of selenium in the treatment of AITD/HT are therefore still needed before we can confidently recommend selenium supplementation in these patients

If the powder does not fully dissolve in the first two to three minutes of swirling, stop and let the vial rest for one to two minutes, then swirl again
Mechanism: BPC-157 modulates the inflammatory response, helping to decrease swelling and pain
