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Extensive research has indicated that metformin exhibits notable effectiveness in addressing PCOS-related complications, including cardiovascular diseases, MASLD, MS, and EC, underscoring its significant potential to enhance long-term health outcomes in individuals with PCOS

322 Several aging-related hallmarks have been identified that exacerbate MAFLD, which will be discussed in more detail

Berryman and colleagues revised IGF-1 actions on obesity, and concluded that this molecule possesses direct effects on muscle glucose uptake [160]

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