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-Grape Seed Extract contains natural compounds such as resveratrol and flavonoids with high functional antioxidant activity

Besides having an essential role in cellular detoxification, they also perform various other functions, including responses in stress conditions and signaling

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At the cellular level, UVB induces keratinocytes to release endothelin-1, which leads to a downregulation of E-cadherin expression in melanocytes, thereby disrupting their adhesion and intercellular communication 20,21