glutathione s-transferase pi 1 transferases as mediators of signaling pathways involved in cell proliferation and cell death Structure of Glutathione S-transferase Pi

These observations suggest that GSAAT(C138S) mimics the catalytic and structural properties of GSAAT(WT) ( Figure 6B )

In astrocytes, Nrf2 activators promote the translocation of Nrf2 from the cytoplasm to the nucleus, where it binds to the antioxidant response element (ARE), upregulating the expression of a series of antioxidant and detoxifying enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1)

The peptide is not approved by Health Canada for any therapeutic use, meaning licensed physicians cannot prescribe it and pharmacies cannot dispense it

Conclusions: This work provides new insights to understand the mechanisms related to the adverse effects of aspartame on liver tissue