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doi: 10.1016/j.fct.2007.06.001 5 AkinmoladunA

In the mid-1950s, Fritz and Yue (1963) led to a conceptual framework depicting how carnitine enables long-chain FA esterification to CoA in the extramitochondrial compartment to generate enzymes of -oxidation in the mitochondrial matrix, thus circumventing the permeability issue of the inner membrane to acyl-CoA esters