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Additionally, one copy of the variant likely affected anaerobic performance more than aerobic performance.[ref] A study of elite rowers also found that the A allele was found much less often in the group.[ref] Rheumatoid arthritis/methotrexate studies: AMPD1 deficiency is associated with a good response to methotrexate in rheumatoid arthritis.[ref][ref] Long Covid and lactic acid levels: A study involving long Covid patients found that lactic levels were higher after exercise