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The molecular mechanism involves regulating the activity of proteins such as p21, p27, ERK, and caspase-3, while simultaneously promoting the conversion of microtubule-associated protein 1 light chain 3(LC3)-I to LC3-II to activate autophagy [144]

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153 A smaller study of similar design found pycnogenol, at 100 mg daily, was associated with better vision, lower risks of retinal edema and recurrent retinal vein thrombosis, and lower frequency of adverse side effects compared with aspirin after nine months

These cytokines suppress Runx2 differentiation of BMSCs