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Cholesterol-induced mitochondrial oxidative stress also promotes intracellular lipoprotein accumulation [90]
As a result, the abnormal tumour vasculature can lead to a resistance of tumour cells to radiation therapy and many chemotherapeutics
The excessive use of glucose for energy production makes the brain especially susceptible to oxidative stress, and mitochondrial ETC is the primary ROS source (Cobley et al., 2018)
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