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For years, the renal damage induced by colistin was considered a mere consequence of the detergent activity of this drug on the cell membrane of proximal tubule cells

However, there were no significant differences in rates of hypertension, ischemic heart disease, atrial fibrillation, erectile dysfunction, diabetes mellitus, peripheral atherosclerosis, and chronic obstructive pulmonary disease

The oral formulation is the most significant differentiator: if an oral tablet can produce weight loss comparable to injectable CagriSema, it could fundamentally change how dual pathway obesity therapy is delivered

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