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Astrocyte energy and neurotransmitter metabolism in Alzheimers disease: Integration of the glutamate/GABA-glutamine cycle

This indicated that the inhibition of CPT1 potentially had some effect on the motor impairment but not enough to restore motor function compared to healthy controls

Interestingly, a recent study using a heavy isotope steady-state infusion of BCAA, showed a shift in BCAA oxidation from adipose tissue and liver toward skeletal muscle in obese, insulin resistant mice [84], consistent with the finding that BCKD enzyme activity in liver and adipose tissue is downregulated in animals with obese/insulin-resistant or diabetic states [75, 103, 111, 112, 134,135,136,137,138]

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