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Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]

FreeSurfer regional segmentation was then performed on the unbiased template image, and the hippocampal formation mask was generated by binarizing and combining the labels corresponding to the hippocampus and the entorhinal cortex, while an extended hippocampal formation mask was additionally generated to also include the parahippocampal cortex

The Science: What We Know, What We Think We Know, and What We're Still Learning Let's be direct about the evidence base

They are extremely helpful and have few risks