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However, under certain pathological conditions such as hypoxia and hyperglycemia, there is an overproduction or accumulation of ROS

10.1007/s10495-010-0524-6 [DOI] [PubMed] [Google Scholar] Kwon J

The relationship between half-life and dose range is not arbitrary

The one or more hepatocyte growth factor mimics have a general structural formula , -R 3 -R 3 -NH-(CH 2 ) ir C-NH 2 1 2 3 where i is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine