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The most accepted mechanism of the effect of metformin on vitamin B 12 level is related to the absorption process where metformin antagonism of the calcium cation and interference with the calcium-dependent IF-vitamin B 12 complex binding to the ileal cubilin receptor
On the other hand, gastrointestinal commensal bacteria, such as Bacteroides, Lactobacillus, and Bifidobacterium, can facilitate the development of Treg cells and, by this, increase the osteoblast activity (162)
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Physiotherapists demonstrate targeted exercises focused on strengthening the joint and relieving pain
