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LC-GFP or LC-SYNCRIP plasmids were transfected into cells using Lipofectamine 3000 (L3000015, Thermo Fisher Scientific, USA) according to the manufacturer's instructions to generate control or SYNCRIP-deficient (KO) cells

Combined treatment with low doses of the SIRT1-specific activator SRT2104 and the LDHA inhibitor oxamate exerted significant antitumor effects on GC cells, with limited adverse effects on normal gastric cells

In phase 2 clinical trials, people with obesity who used MariTide achieved up to 20% weight loss after one year, along with significant improvements in blood sugar levels and other metabolic markers
