glutathione transferase inhibitors transferases as mediators of signaling pathways involved in cell proliferation and cell death Glutathione-S-Transferases as Potential Targets for
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Martin W, Baross J, Kelley D, Russell MJ

doi: 10.1097/01.CCM.0000057843.47705.E8

Together, these data show that HNE inhibits NLRP3 assembly and activation in mouse and human cells, but has no effect on AIM2 and NLRC4

Also of relevance are the mitochondrial alterations and lysosome dysfunction seen in human fibroblasts from sporadic AD patients [57]
