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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted
To be clear: these were not individuals with a known Vitamin B deficiency
It usually involves difficult or irregular bowel movements, accompanied by hard, dry motions which can be painful to pass
Nourbakhsh, M
