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It should be noted that RES is also recognized as a PAINS compound, and its poor water solubility and rapid metabolism limit its pharmacological effects, making the current therapeutic evidence presenting dispersion, mechanism presenting uncertainty and adverse drug reactions, so more high-quality in vivo studies and clinical data are needed to verify its exact pharmacological effects and safety

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[DOI] [PubMed] [Google Scholar] Zapata-Prez R, Tammaro A, Schomakers BV, Scantlebery AML, Denis S, Elfrink HL, et al

Pentade-capeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin