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The median age was 58 years (range 22 to 87 years)
As of 2024, the MHRA (Medicines and Healthcare products Regulatory Agency) has authorised Mounjaro for use in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity, such as hypertension, dyslipidaemia, or obstructive sleep apnoea
Those conditions relate to pancreas and kidney
Details of the TCA cycle gene mutations and their associations to cancer syndromes are covered in the Metabolic Alterations Associated with Cancer page and so will only be briefly reviewed in this page
