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ANTIAGEING EFFECT Skin ageing can be extrinsic or intrinsic. UV irradiation results in extrinsic ageing

This process primarily occurs in the liver, the bodys main organ for detoxification.[ref] The CYP450 enzymes have iron and oxygen in them and, through a redox reaction, can make a drug, toxin, or endogenous substance more polar

Atrophic astrocytes with reduced complexity and blunt and coarse processes are present in the white matter and are characterized by impaired GFAP-related structures, suppressed expression of S100B, aberrant maturation and loss of astrocytic functions ultimately translated into white matter disintegration 336,337

[262], involving both children and young adults