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Epub 2020 Feb 22

Although the synthesis of triazole-based PROTACs follows the principles of green chemistry, these compounds have low solubilities and are challenging from a pharmaceutical industrial viewpoint due to the difficulty of scale-up

When comparing their fibroblasts, it was found that Nip3-like protein X, which may mediate a Parkin/PINK1-independent pathway in eliminating damaged mitochondria, was highly upregulated in the asymptomatic carrier

Although further study is necessary to understand the reason for the lack of growth factor receptor responses in some but not all GPx-1-deficient cells, the end result of these attenuated pro-survival pathways would be decreased cell growth and augmented apoptosis