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Rather, the exclusion of p53 itself has been reported to induce apoptosis directly when located to mitochondria (Mihara et al., 2003), thereby explaining the FOXO4-DRI effects

They include nicotinic acid (also known as niacin) composed of a pyrimidine ring bound to a carboxylic group (pyridine-3-carboxylic acid), nicotinamide (also known as niacinamide) composed of a pyrimidine ring bound to a carboxamide group (pyridine-3-carboxamide), and nicotinamide riboside

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The sixth coordination site, the center of reactivity, is variable, being a cyano group (-CN), a hydroxyl group (-OH), a methyl group (-CH3) or a 5-deoxyadenosyl group (here the C5 atom of the deoxyribose forms the covalent bond with Co), respectively, to yield the four B12 forms mentioned above