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For this purpose, we calculated for all pairs of consecutive samples from the same subject the Jaccard index, a beta-diversity metric that indicates the fraction of shared features between samples, both at compositional and functional levels, considering ASV and TIGRFAM annotations, respectively

FIGURE 1 3.2 Characteristics and quality evaluation of literature There are 1737 patients altogether in the sample size of the 21 studies, which include 871 patients in the intervention group and 866 patients in the control group

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