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The mitochondrial pathway can be triggered by hypoxia, ROS, and DNA damage, mainly leading to apoptosis by disrupting the balance of Bcl-2 family proteins

10.1212/WNL.49.6.1570

Most importantly, this study suggested that high levels of NRF2 expression could be correlated with a relative resistance to platinum-based chemotherapy and with an inferior survival rate (75)

Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, et al
