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Those with hypothyroidism should use caution since it can interfere with thyroid hormone

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Neurobiol Aging 1995;16:1-4

Glutamate acts through eight ionotropic and metabotropic receptor subtypes (mGluR1mGluR8) that have been classified into three groups: Group I receptors (mGluR1 and mGluR5) are coupled to G q proteins and phospholipase C and are involved in central sensitization and pain chronification