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The heart undergoes significant remodelling to keep up with the demand
it also may stimulate the formation of new neuronal connections and the formation of new neurons from stem cells

This reduction in PP2A activity decreases AR resensitization, evidenced by increased 1 - and 2 -AR phosphorylation and increased endosomal accumulation of phosphorylated 2 -ARs

10.1002/pmic.200401287 Proteomics 65 KearneyJ
