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Compound heterozygous MTHFR gene variants (677T/1298C) characteristically exhibit hypomethylation (Ren et al., 2018)

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According to data from the World Health Organization (WHO), COPD is the third leading cause of death worldwide, causing 3.23 million deaths in 2019, with more than 80% of these deaths occurred in low- and middle-income countries (7, 8)