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Focused vascular ultrasound for the assessment of atherosclerosis: a proof-of-concept study

All subjects completed two testing sessions, seven days apart, 90 minutes following oral ingestion of either 4.5 grams GPLC or 4.5 grams cellulose (PL), in randomized order

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That accumulation occurs thanks to 2 pathways: the first is the poor or null elimination of that metal by the biliary tract, which causes an elevated serum concentration, and the second is portal hypertension and the creation of collateral circulation, favored by the disruption of the blood-brain barrier, as the pathway of propagation to the brain