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Nevertheless, therapeutic hypothermia is only partially effective (5760), and many infants with HIE remain at substantial risk of death or severe long-term neurodevelopmental impairments (55)
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[64], treatment with acetyl-l-carnitine (500 mg twice daily intramuscularly for 10 days followed by 2000 mg daily administered orally for 355 days) resulted in improvement in neurophysiological parameters and pain reduction over a 1-year period [64]
