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Dysregulation of this pathway through altered dimerization, post-translational modifications, or impaired regulation contributes to the pathophysiology of Alzheimers disease, Parkinsons disease, Huntingtons disease, and amyotrophic lateral sclerosis, leading to protein aggregation, mitochondrial dysfunction, and neuroinflammation

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Research demonstrates improved muscle repair following injury, enhanced recovery from exercise, and protection against muscle wasting conditions including Duchenne muscular dystrophy