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This lid, to a certain degree, shields the catalytic center against environmental stressors, but also restricts access to the active site, leading to reduced catalytic activity 10
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However, this effect seems to be partial, as the inhibition of GSK3 compromised but did not fully abrogate the function of IL-16
Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR
