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It should be noted that improved glucose homeostasis and increased insulin sensitivity in Nrf2 / mice has not been reported by all researchers, and in one of the early studies it was reported that the mutant mice show lower plasma insulin levels and an impaired glucose tolerance test [229]

It is now apparent that many xenobiotics are metabolized entirely by pathways that do not involve phase I reactions

Hood S, Amir S (2017) The aging clock: circadian rhythms and later life

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