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The phosphorylated substrates provide specific docking sites for intracellular effectors, including the p85 regulatory subunit of PI-3K and Growth-factor-receptor-bound protein-2 (Grb2), thus leading to the activation of two major signaling pathways, the PI-3K-PKB/AKT pathway and the Ras-MAPK pathway (Figure 1)
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[DOI] [PMC free article] [PubMed] [Google Scholar] [234].Cao B, Li J, Zhu J, et al
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