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In chronic autoimmune diseases like rheumatoid arthritis (RA), an overabundance of pro-inflammatory (M1) macrophages and hyperactive immune cells (HICs) in the joint synovium, along with increased ROS concentrations, is commonly observed
A study reported that the serum ferritin level may also serve as an early indicator of adipose tissue dysfunction, as it is associated with elevated lipid metabolism markers [55]
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