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Additionally, studies have shown that GPX4 expression is reduced to varying degrees in both cells and kidneys in DKD models, weakening cellular resistance to oxidative stress and promoting lipid peroxidation, ultimately leading to ferroptosis ( Recent studies using cellular and animal models have confirmed that inhibiting ferroptosis in renal cells slows the progression of DKD

Moreover, PorB activation of TLR2 has been demonstrated to enhance bacterial internalization, suggesting that the expression of different PorB variants may be another factor affecting meningococcal internalization (Toussi et al., 2016)

10.1016/j.biopha.2020.110607 129 LiuT.YangQ.ZhangX.QinR.ShanW.ZhangH.et al (2020b)

Fan Q-M, Jing Y-Y, Yu G-F, et al
