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Variables that increase the risk of toxicity include the type of LA and dose, site of injection, the patients comorbidities, extremes of age, and small size or limited muscle mass

Pereira A (2020) Chapter Seven - Classical-quantum interfaces in living neural tissue supporting conscious functions

Female partners were excluded if they exhibited diminished ovarian reserve, defined as fewer than five oocytes retrieved in a prior IVF cycle or elevated early follicular phase FSH levels, or were aged over 39 years (218). The Cochrane review published in 2019 showed that although the use of AOXs for men prior to IVF did not improve the CPR (OR = 2.64, 95% CI 0.94 to 7.41), the LBR increased significantly (OR = 3.61, 95% CI 1.27)