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This entire process prevents the cell from producing misfolded or altered proteins.[ref] Studies show that high homocysteine levels cause ER stress and activate the unfolded protein response pathway, which can lead to cell death

Low Hcy might mean too many B vitamins or fast conversion to cysteine, lowering glutathione (GSH), an important antioxidant

they create what researchers refer to as a massive immunological "energy sink." Because the immune cells (particularly T-cells and memory lymphocytes) are trapped in a state of severe oxidative stress, they are forced to consume excessive amounts of the host's energy just to survive the ongoing cellular damage and attempt repairs